ginkgo biloba + huperzine A

Ginkgo biloba + huperzine A is a combination dietary supplement composed of two plant-derived compounds: extracts of the leaves of Ginkgo biloba and the alkaloid huperzine A from Huperzia serrata. Both ingredients have independent pharmacological actions relevant to cognitive function enhancement, especially in the aging population. - **Ginkgo biloba** contains flavonoids, terpenoids, and terpene lactones (ginkgolides and bilobalide) that act as antioxidants, support cerebral blood flow, and have neuroprotective effects by inhibiting platelet-activating factor, reducing oxidative stress, balancing multiple neurotransmitter systems (including glutamatergic, dopaminergic, and cholinergic signaling), and protecting neuronal membranes and mitochondria. - **Huperzine A** is a potent, reversible, and selective inhibitor of acetylcholinesterase (AChE), leading to increased acetylcholine levels in synaptic clefts, enhancing cholinergic neurotransmission, and providing neuroprotection. It also antagonizes NMDA receptor activity, inhibits beta-amyloid neurotoxicity, and exerts antioxidative, antiapoptotic, and additional neuroprotective actions. The combination is marketed for mental fitness, alertness, memory, and cognitive performance improvement, primarily targeting age-related memory decline and cognitive impairment[1][2][3].

Brand names

Ginkozin