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ginkgo biloba extract + dipyridamole

Development stage: Unknown
Lead developer: Guizhou Yibai Pharmaceutical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Intravenous

Overview

Ginkgo biloba extract + dipyridamole is a combination pharmaceutical product, typically administered as an intravenous injection, widely used in China for cardiovascular and cerebrovascular disorders. The formulation combines the antiplatelet and vasodilatory properties of dipyridamole with the neuroprotective and microcirculatory benefits of Ginkgo biloba extract. Dipyridamole functions by inhibiting phosphodiesterase enzymes and the cellular uptake of adenosine, leading to increased cAMP/cGMP levels and inhibition of platelet aggregation. Ginkgo biloba extract, containing flavonoids and terpene lactones (such as ginkgolides), acts as a free radical scavenger and a platelet-activating factor (PAF) receptor antagonist. The combination is primarily indicated for ischemic stroke, coronary heart disease, and thromboembolic prophylaxis.

Brand names: Ginkgo Dipyridamole Injection
Other names: Ginkgo biloba extract and dipyridamole injectionginkgo dipyridamole

Targets

PTAFR (Platelet-activating factor receptor)PDE5 (Phosphodiesterase 5A)PDE3A (Phosphodiesterase 3A)ENT1 (Solute carrier family 29 member 1)PDE11A (Phosphodiesterase 11A)PDE10A (cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A)

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