Drug intelligence / Profile preview

ginkgo lactone

Development stage
Phase 4
Lead developer
Baiyu Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Intradermal, Intravenous
01

Overview

Ginkgo lactone (marketed as Ginkgo Lactone Injection under the brand name Jingelai) is a standardized botanical extract of terpene lactones from *Ginkgo biloba* leaves, developed by Chengdu Baiyu Pharmaceutical. It primarily consists of ginkgolides (including ginkgolide A, B, and C) and bilobalide. Ginkgo lactone acts as a potent and selective antagonist of the platelet-activating factor (PAF) receptor, thereby inhibiting PAF-induced platelet aggregation, reducing inflammation, and providing neuroprotective effects. It is approved in China for the treatment of mild-to-moderate acute ischemic stroke and during the recovery phase of stroke (phlegm and blood stasis syndrome).

Brand names
Jingelai金阁莱
Other names
ginkgo lactone injectionginkgolide injection银杏内酯注射液
02

Targets

PTAFR (Platelet-activating factor receptor)

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