Drug intelligence / Profile preview

ginkgo leaf extract

Development stage
Unknown
Lead developer
The Chinese University of Hong Kong
Modality
Small Molecules
Administration
Oral
01

Overview

Ginkgo leaf extract is a standardized herbal preparation derived from the leaves of the Ginkgo biloba tree, typically containing specific concentrations of flavone glycosides and terpene lactones. In a clinical research program led by the Chinese University of Hong Kong (notably trial NCT00164749), a 120 mg daily dose of ginkgo extract was utilized as a foundational therapy in patients with mild to severe Alzheimer's disease to evaluate the additive effects of curcumin. The extract is thought to exert neuroprotective effects through multiple mechanisms, including the antagonism of platelet-activating factor (PAF) receptors, reduction of oxidative stress, and potential inhibition of amyloid-beta aggregation and related neurotoxicity.

Other names
Ginkgo biloba extractGBEstandardized ginkgo leaf extract
02

Targets

Aβ (Amyloid-beta peptides and aggregates)PTAFR (Platelet-activating factor receptor)

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