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Ginkgolide
- Development stage
- Phase 4
- Lead developer
- Second Affiliated Hospital of Zhejiang University School of Medicine
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Ginkgolide is a pharmaceutical-grade injection containing terpene lactones (specifically ginkgolides A, B, and C) derived from *Ginkgo biloba* extract. Developed and manufactured by Chengdu Baiyu Pharmaceutical, it is primarily used as an adjunctive treatment for acute ischemic stroke. The drug functions as a potent antagonist of the platelet-activating factor (PAF) receptor, thereby inhibiting platelet aggregation and reducing the risk of thrombus formation and reocclusion following thrombolysis. Additionally, it exhibits neuroprotective and anti-inflammatory properties by modulating cytokines such as TNF-α and IL-6, protecting the blood-brain barrier, and reducing ischemia-reperfusion injury. It has been evaluated in the Phase 4 GIANT trial by the Second Affiliated Hospital, School of Medicine, Zhejiang University, in combination with intravenous alteplase.
- Brand names
- Ginkgolide
- Other names
- ginkgolide injectionterpene lactoneginkgolides Aginkgolides Bginkgolides C
02
Targets
PTAFR (Platelet-activating factor receptor)
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