ginkgolide-C

Ginkgolide C is a diterpene lactone isolated from the leaves of *Ginkgo biloba*. It belongs to the class of organic compounds known as ginkgolides and bilobalides, which are characterized by a rigid hexacyclic structure. Ginkgolide C exhibits multiple biological activities including anticoagulant, neuromodulatory, antioxidative, and anti-apoptotic effects. Mechanistically, it acts as an antagonist at platelet-activating factor (PAF) receptor and inhibits Gamma-aminobutyric acid type A receptor and Glycine receptor alpha 1 subunit. It also increases levels of matrix metalloproteinase 9 (MMP9), cAMP, and cGMP; suppresses thromboxane A2 production; inhibits platelet aggregation; scavenges free radicals; and modulates inflammatory pathways such as MAPK and TLR signaling. These properties have led to research interest in its potential for neuroprotection (e.g., in Alzheimer’s disease), anti-inflammatory action, inhibition of platelet aggregation (anticoagulant effect), and antioxidative stress reduction[1][2][4][6].

Other names

GCGinkgolide C