ginkgolide J

Ginkgolide J is a terpene lactone and a minor constituent of the terpene trilactone mixture found in Ginkgo biloba leaves. It belongs to the class of organic compounds known as ginkgolides and bilobalides, which are diterpene lactones. Ginkgolide J exhibits neuroprotective and antioxidative activities, including prevention of amyloid-β-induced cell death in cellular models of Alzheimer’s disease and inhibition of superoxide and hydroperoxyl radical formation. Mechanistically, it acts as an inhibitor of glycine receptor (GlyR)-operated channels with an IC50 around 2 μM. It also demonstrates anti-inflammatory effects by inhibiting MAPK (mitogen-activated protein kinase) pathways, toll-like receptor signaling (TLR), arachidonic acid inflammatory pathway components such as IL-5 and IL-13, TNF receptor-mediated apoptosis, and functions as a free radical scavenger[1][3][4][5][6].

Other names

7beta-Hydroxyginkgolide A