Drug intelligence / Profile preview

ginkgolone ester

Development stage
Unknown
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Ginkgolone ester is a standardized pharmaceutical extract derived from the leaves of *Ginkgo biloba*, primarily composed of ginkgo flavone glycosides and terpene lactones. Developed and extensively researched by institutions such as Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, it is utilized for its neuroprotective, cardiovascular, and potential anti-tumor properties. The extract functions primarily by antagonizing platelet-activating factor (PAF) receptors and acting as a potent free radical scavenger, which collectively improve microcirculation and mitigate oxidative stress. In the context of cognitive impairment and vascular dementia, ginkgolone ester is used to enhance cerebral blood flow and protect neuronal integrity. In oncology, specifically breast cancer, it is being investigated for its ability to inhibit tumor cell proliferation and induce apoptosis, often serving as an adjuvant therapy to enhance the efficacy of chemotherapy or reduce its associated toxicities.

Brand names
Yinxing Tongzhi
Other names
Ginkgo Leaf ExtractGinkgo Flavone EsterGinkgo Flavonoid EsterYinxing TongzhiGinkgo Biloba Extract
02

Targets

PTAFR (Platelet-activating factor receptor)

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