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ginsan
- Development stage
- Preclinical
- Lead developer
- Korea Institute of Radiological and Medical Sciences
- Administration
- Oral, Intraperitoneal
01
Overview
Ginsan is a specific acidic polysaccharide isolated from the root of *Panax ginseng*. It functions as an immunomodulator and antineoplastic agent by stimulating the production of various cytokines, including interleukin-2 (IL-2), interferon-gamma (IFN-γ), interleukin-1 alpha (IL-1α), and granulocyte-macrophage colony-stimulating factor (GM-CSF). This cytokine induction facilitates the generation of lymphokine-activated killer (LAK) cells from both natural killer (NK) and T cell populations. Ginsan has demonstrated efficacy in preclinical models for inhibiting the incidence of lung tumors and reducing melanoma metastasis, often showing synergistic effects when combined with recombinant IL-2. Additionally, it has been investigated for its potential radioprotective properties.
- Other names
- Panax ginseng acidic polysaccharideacidic polysaccharide from Panax ginseng
02
Targets
IL-2 (Interleukin 2)IL1A (Interleukin 1 alpha)GM-CSF (Granulocyte-macrophage colony-stimulating factor)IFNG (Interferon gamma)
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