ginsenoside F1

Ginsenoside F1 is a dammarane-type triterpene saponin (triterpenoid) originally found in Panax species (including Panax ginseng and Panax notoginseng), often produced as a metabolite of ginsenoside Rg1. It exhibits cytoprotective, anti-apoptotic (apoptosis inhibitor), anti-aging, antioxidant, anti-cancer, and keratinocyte-protective effects. Ginsenoside F1 enhances natural killer (NK) cell cytotoxicity through insulin-like growth factor 1 (IGF-1)-mediated signaling and exhibits competitive inhibition of CYP3A4 with weaker CYP2D6 inhibition. Preclinical data indicate inhibition of p38 MAP kinase with potential implications in cancer immunotherapy and neurodegenerative disease. It is not an approved pharmaceutical but is an active ingredient of interest in natural product research and cosmetics development[1][2][3][4][6][7][8][10].

Other names

53963-43-2CHEBI:77150G-F1G-F-1G-F 1