ginsenoside rh2

Ginsenoside Rh2 is a natural triterpene saponin compound derived from Panax ginseng. It exists as two stereoisomers—20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2—with the S-form generally exhibiting stronger biological activity. Ginsenoside Rh2 has demonstrated potent anticancer and anti-inflammatory effects in preclinical studies. Its mechanisms of action include modulation of multiple signaling pathways such as PI3K/Akt/mTOR, Src/Raf/ERK, PDZ-binding kinase/T-LAK cell-originated protein kinase, epidermal growth factor receptor (EGFR), p53 activation, caspase-3 induction (apoptosis), and regulation of reactive oxygen species. It can induce apoptosis and cell cycle arrest in cancer cells and modulate immune responses by activating T lymphocytes. Ginsenoside Rh2 has shown efficacy against various cancers including breast cancer, colorectal cancer, hepatocellular carcinoma, gastric cancer, oral cancer, leukemia (T-ALL), melanoma models in animals as well as nonmalignant diseases like ulcerative colitis and depression[1][5][6]. Despite promising results in vitro and animal models with low toxicity profiles reported so far[1], its clinical development is limited by poor oral bioavailability[1]. No major pharmaceutical company or brand name product is currently associated with this compound.

Other names

ginsenoside-Rh2ginsenoside-Rh-2ginsenoside-Rh 2GRh2GRh-2GRh 2