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gisadenafil besylate
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gisadenafil besylate (also known as UK-369,003-Besylate) is a potent, selective, and orally bioavailable small molecule phosphodiesterase-5 (PDE5) inhibitor developed by Pfizer. It works by preventing the degradation of cyclic guanosine monophosphate (cGMP), thereby promoting smooth muscle relaxation and vasodilation. Gisadenafil besylate was investigated in Phase 2 clinical trials for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), with or without comorbid erectile dysfunction (ED), as well as overactive bladder (OAB) and chronic obstructive pulmonary disease (COPD). The drug was evaluated in both immediate-release (IR) and modified-release (MR) oral formulations, but development was subsequently discontinued.
- Other names
- Gisadenafil besylateGisadenafil benzenesulfonategisadenafil
02
Targets
PDE5A (Cyclic GMP-specific phosphodiesterase 5A)PDE6 (Phosphodiesterase 6)
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