Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
glabrescione B
- Development stage
- Preclinical
- Lead developer
- Sapienza University of Rome
- Modality
- Small Molecules
- Administration
- Intranasal, Intravenous
01
Overview
Glabrescione B is a naturally occurring methoxyisoflavone, originally isolated from the seeds of *Derris glabrescens*, that acts as a selective, direct inhibitor of the GLI1 transcription factor. GLI1 is a key downstream effector of the Hedgehog (Hh) signaling pathway, which is aberrantly activated in various malignancies. Glabrescione B binds directly to the zinc finger domain of GLI1, disrupting its interaction with DNA and suppressing Hh-mediated transcription. Preclinical studies have demonstrated its efficacy in reducing cell proliferation, self-renewal, and clonogenicity in Hedgehog-dependent cancers, including medulloblastoma, glioma, basal cell carcinoma, and intrahepatic cholangiocarcinoma. To overcome its poor water solubility, researchers have developed advanced delivery systems, such as mPEG5kDa-cholane micelles and hyaluronic acid (HA) nanohydrogels.
- Other names
- 3-[3,4-bis(3-methylbut-2-enoxy)phenyl]-5,7-dimethoxychromen-4-one5,7-dimethoxy-3',4'-diprenyloxyisoflavoneGlaB
02
Targets
GLI1
Beyond the preview
Go deeper on glabrescione B.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on glabrescione B.