glabridin

Glabridin is a prenylated isoflavan isolated from the roots of Glycyrrhiza glabra (licorice), acting as a phytoestrogen and possessing diverse biological activities including anti-inflammatory, antioxidant, antimicrobial, anti-tumor, bone protective, neuroprotective, hepatoprotective, cardiovascular protective, anti-obesity, and anti-diabetes effects. Mechanistically, it modulates several signaling pathways (e.g., NF-κB, MAPK, Wnt/β-catenin, PI3K/AKT, AMPK), inhibits tyrosinase, P-glycoprotein, and CYP2E1, and activates peroxisome proliferator-activated receptor γ (PPARγ). It is a positive allosteric modulator of GABAA receptor, exerts platelet aggregation inhibition (implicating utility in thromboembolic disorders), and acts as a skin-whitening and cosmetic agent. Clinical use is limited by poor water solubility and bioavailability; efforts to improve delivery include nanoemulsions and microneedles[1][2][4][5][6][7].

Other names

glabridin(R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol1,3-Benzenediol, 4-(3,4-dihydro-8,8-diMethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-(R)-isoflavanGlabridin/OIL SOLUBLE LICORICE(GLYCYRRHIZA) EXTRACTGlabridin/Propylene Glycol