Glafenine

Glafenine is a nonsteroidal anti-inflammatory drug (NSAID) of the anthranilic acid derivative class, used historically for the relief of various types of pain. Its mechanism of action involves inhibition of cyclooxygenase enzymes, particularly cyclooxygenase 2 (COX2), thereby reducing prostaglandin synthesis and exerting analgesic and anti-inflammatory effects. It was withdrawn from many markets due to a high incidence of severe adverse reactions, including anaphylaxis and acute kidney failure. Recent research has also shown that glafenine can act as a proteostasis modulator by rescuing certain cystic fibrosis transmembrane conductance regulator (CFTR) mutants via COX2 inhibition in the arachidonic acid pathway[1][2][4][6].

Brand names

Glafenin

Other names

glafenineGlafénineGlafeninaGlafeninumGlycerylaminophenaquine