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GLB-005

Development stage: Preclinical
Lead developer: GluBio Therapeutics
Modality: Molecular Glues → Targeted Protein Degraders (TPDs) → Small Molecules

Overview

GLB-005 is a highly selective small-molecule molecular glue degrader developed by GluBio Therapeutics. It targets the WIZ protein (Widely Interspaced Zinc Finger Motifs), acting as a WIZ zinc finger modulator to induce targeted protein degradation. The drug is being investigated primarily for hematological disorders, specifically sickle cell anemia and beta-thalassemia. As of the latest updates, it remains in preclinical or lead optimization stages and has not yet entered clinical trials[1][2][3].

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