Drug intelligence / Profile preview

GlcNAc-GlcN

Development stage
Unknown
Lead developer
Suzhou Bawei Medicine Development & Research Institute
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

GlcNAc-GlcN is a heterodisaccharide, specifically 4-O-(N-acetyl-β-D-glucosaminyl)-D-glucosamine, which is a product of chitin degradation. It is formed from N,N'-diacetylchitobiose ((GlcNAc)2) through the action of chitin oligosaccharide deacetylase (COD) or a combination of chitinase and COD. In various *Vibrio* bacteria, GlcNAc-GlcN acts as a crucial signaling molecule. It induces the production of chitinolytic enzymes, particularly chitinase, thereby enhancing the bacteria's ability to metabolize chitin. Furthermore, it functions as an effective chemoattractant for COD-producing *Vibrio* species and stimulates polar flagellum rotation.

Other names
β-N-acetyl-d-glucosaminyl-(1,4)-d-glucosamine4-O-(N-acetyl-β-D-glucosaminyl)-D-glucosamine
02

Targets

CHIT1 (Chitotriosidase)

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