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Glimecare-M2 is a fixed-dose combination oral antidiabetic medication developed and manufactured by Apgar Pharmaceuticals. It contains two active pharmaceutical ingredients: glimepiride (2 mg) and metformin. Glimepiride is a second-generation sulfonylurea that lowers blood glucose by stimulating insulin secretion from pancreatic beta cells through the inhibition of ATP-sensitive potassium channels. Metformin is a biguanide that improves glycemic control by decreasing hepatic glucose production, reducing intestinal glucose absorption, and increasing peripheral insulin sensitivity. This combination therapy is indicated for the management of type 2 diabetes mellitus in adult patients when glycemic control is not achieved with diet, exercise, or monotherapy with either agent alone. It is part of Apgar's commercial portfolio of generic medicines within their Diabetic Care therapeutic category.
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