Drug intelligence / Profile preview

glimepiride + metformin

Development stage
Phase 4
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral
01

Overview

Glimepiride + metformin is a fixed-dose combination of two oral antidiabetic agents used in the management of type 2 diabetes mellitus, particularly in patients whose blood sugar levels are not adequately controlled by diet, exercise, or monotherapy. Glimepiride is a sulfonylurea that stimulates insulin secretion from pancreatic beta cells, thereby increasing insulin availability. Metformin is a biguanide that reduces hepatic glucose production, delays intestinal glucose absorption, and increases peripheral insulin sensitivity. Together, this combination addresses both impaired insulin secretion and insulin resistance to improve glycemic control[5][8][2]. The drug is widely prescribed globally and available in multiple strengths under various brand names.

Brand names
Asoride-MBigonylMatce-G1Matce-G-1Matce-G 1Matce-G2Matce-G-2Matce-G 2Dixi MVikpride 1Vikpride1Vikpride-1Vikpride 2Vikpride2Vikpride-2METFORISE-G2 FORTE TABLETMETFORISE-G-2 FORTE TABLETMETFORISE-G 2 FORTE TABLETGlimitab M
Other names
glimepiride/metformin fixed-dose combination
02

Targets

SUR2A (ATP-binding cassette sub-family C member 9)ND1 (Mitochondrial electron transport chain complex I)SUR1 (Sulfonylurea receptor 1)AMPK (Adenosine monophosphate–activated protein kinase)

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