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glioma-associated antigen peptide-pulsed autologous dendritic cell vaccine
- Development stage
- Phase 1
- Lead developer
- UCLA Jonsson Comprehensive Cancer Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
The glioma-associated antigen (GAA) peptide-pulsed autologous dendritic cell vaccine is an investigational personalized cellular immunotherapy developed by the UCLA Jonsson Comprehensive Cancer Center in collaboration with the National Cancer Institute. This biologic therapy utilizes a patient's own dendritic cells, which are harvested via leukapheresis and matured ex vivo. These cells are then pulsed with synthetic peptides corresponding to glioma-associated antigens (GAAs) that are frequently overexpressed in malignant gliomas. The vaccine is specifically designed for patients who are HLA-A*0201 positive. Upon administration, the dendritic cells present these antigens to the host immune system to prime and activate a cytotoxic T-lymphocyte (CTL) response against the tumor cells. It has been evaluated in Phase I clinical trials (notably NCT00612001) for the treatment of malignant gliomas, including glioblastoma multiforme.
- Other names
- GAA peptide-pulsed DC vaccineGAA peptide-pulsed dendritic cell vaccineglioma-associated antigen peptide-pulsed dendritic cell vaccine
02
Targets
γδ TCR (T-cell receptor)pMHC (Peptide-MHC complex family)
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