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glipizide GITS
- Development stage
- Approved
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Glipizide GITS (Gastrointestinal Therapeutic System) is an oral blood-glucose-lowering drug of the sulfonylurea class formulated as a once-a-day controlled release tablet. It works by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The insulinotropic response to meals is enhanced with glipizide GITS administration in diabetic patients. The medication is contained within a non-absorbable shell specially designed to slowly release the drug so the body can absorb it gradually, maintaining effective plasma concentrations throughout the 24-hour dosing interval with less peak-to-trough fluctuation than twice-daily dosing of immediate-release glipizide.
- Brand names
- GLUCOTROL XLGlipizide XLMINIDIAB OD
- Other names
- Gastrointestinal Therapeutic System
02
Targets
SUR1 (Sulfonylurea receptor 1)
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