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gliquidone
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gliquidone is a second-generation sulfonylurea antidiabetic drug used in the management of type 2 diabetes mellitus. It acts as an ATP-dependent potassium (KATP) channel blocker on pancreatic beta cells, leading to cell membrane depolarization, activation of voltage-dependent calcium channels, increased intracellular calcium influx, and subsequent stimulation of insulin secretion. This mechanism lowers blood glucose by enhancing endogenous insulin release and promoting glucose uptake into peripheral tissues. Gliquidone is primarily metabolized hepatically and is notable for its minimal renal excretion, making it suitable for patients with mild to moderate renal impairment. The drug is marketed under several brand names globally and was developed by Boehringer Ingelheim[1][4][7].
- Brand names
- GlurenormDevotanFordiabGlidiabGlunormalGlurenorJie ShiKa Rui LinLodem
- Other names
- GliquidonumGliquidona
02
Targets
KATP channel (ATP-sensitive potassium channel)
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