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Drug intelligence / Profile preview
GliSODin
- Development stage
- Unknown
- Lead developer
- Isocell
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Oral
01
Overview
GliSODin is an oral nutraceutical supplement composed of a melon-derived superoxide dismutase (SOD) enzyme combined with gliadin, a wheat protein. The gliadin component serves as a protective carrier, preventing the degradation of SOD by gastric acid and allowing its absorption in the small intestine. As a potent antioxidant, SOD works to neutralize reactive oxygen species and restore antioxidant balance, which is hypothesized to play a role in the pathophysiology of melasma. The Centre Hospitalier Universitaire de Nice conducted a randomized, placebo-controlled trial (NCT03878433) evaluating GliSODin (500 mg/day) in combination with sunscreen for the treatment of melasma severity. The study aimed to leverage SOD's ability to mitigate oxidative stress-induced melanogenesis.
- Brand names
- GliSODinGliSODin Skin BrighteningGliSODin Anti-Aging
- Other names
- SOD-gliadinSuperoxide dismutase-gliadin complex
02
Targets
Misfolded SOD1
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