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Drug intelligence / Profile preview
Globo-H-GM2-sTn-TF-Tn-KLH
- Development stage
- Unknown
- Lead developer
- Memorial Sloan Kettering Cancer Center
- Modality
- Vaccines & Immunotherapeutics, Peptides
- Administration
- Subcutaneous
01
Overview
Globo-H-GM2-sTn-TF-Tn-KLH is a synthetic unimolecular pentavalent cancer vaccine developed by Memorial Sloan Kettering Cancer Center (MSKCC) for the treatment of epithelial ovarian, fallopian tube, and peritoneal cancers. The vaccine consists of five tumor-associated carbohydrate antigens (TACAs)—Globo-H, GM2 (ganglioside M2), sTn (sialyl-Tn), TF (Thomsen-Friedenreich antigen), and Tn antigen—chemically synthesized on a single peptide backbone and conjugated to keyhole limpet hemocyanin (KLH) as a carrier protein. Administered with the immunological adjuvant QS-21, the vaccine is designed to induce a polyvalent antibody response against multiple targets overexpressed on the surface of ovarian cancer cells, potentially overcoming tumor heterogeneity and antigen loss.
- Other names
- Unimolecular pentavalent vaccinePentavalent carbohydrate vaccineGlobo-H-GM2-sTn-TF-Tn-KLH conjugateGlobo-H-GM-2-sTn-TF-Tn-KLH conjugateGlobo-H-GM 2-sTn-TF-Tn-KLH conjugate
02
Targets
Globo-HTF antigen (Thomsen-Friedenreich antigen)Tn (Tn antigen)STn-MUC1 (Sialyl-Tn-MUC1)GM2 (Ganglioside GM2)
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