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glochidion velutinum n-butanol fraction
- Development stage
- Preclinical
- Administration
- Oral
01
Overview
G. velutinum n-butanol fraction is a phytochemical extract derived from the leaves of the plant *Glochidion velutinum*. It is prepared by fractionating a crude methanolic extract using n-butanol to isolate a specific profile of secondary metabolites, including phenolic compounds and flavonoids. In preclinical research, this fraction has been evaluated for its cytotoxic activity against prostate cancer (PC-3) and breast cancer (MCF-7) cell lines. The extract's bioactivity is attributed to a complex mixture of phytochemicals such as epigallocatechin gallate (EGCG), ellagic acid, isovitexin, and rutin, which are known to possess antineoplastic properties. Studies indicate that the fraction exhibits selective toxicity toward cancer cells with negligible effects on normal macrophages, suggesting potential for further development as a therapeutic lead in oncology.
- Other names
- G. velutinum n-butanol fractionn-butanol fraction of Glochidion velutinum
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