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GLR203101
- Development stage
- Preclinical
- Lead developer
- Gan & Lee Pharmaceuticals
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
GLR203101: sourced facts only. name: "Herein, we report the discovery of a selective and orally bioavailable SMARCA2 PROTAC degrader, GLR203101." [DOI:10.1158/1538-7445.am2025-405]; target: "Herein, we report the discovery of a selective and orally bioavailable SMARCA2 PROTAC degrader, GLR203101." [DOI:10.1158/1538-7445.am2025-405]; developer: "Gan & Lee Pharmaceuticals, Beijing, China." [DOI:10.1158/1538-7445.am2025-405]; modality: "Herein, we report the discovery of a selective and orally bioavailable SMARCA2 PROTAC degrader, GLR203101." [DOI:10.1158/1538-7445.am2025-405]; stage: "After 24 hours of oral administration of GLR203101, a robust degradation of SMARCA2 while sparing SMARCA4 was observed in transplanted tumors in the xenograft model." [DOI:10.1158/1538-7445.am2025-405]
02
Targets
SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 2)
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