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GLS-5140
- Development stage
- Preclinical
- Lead developer
- GeneOne Life Science
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
GLS-5140 is a prophylactic DNA vaccine developed for the prevention of severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (formerly known as SFTS virus or SFTSV). The mechanism of action involves immunostimulation to induce protective immune responses against the virus. It is being developed by GeneOne Life Science in collaboration with Korea Advanced Institute of Science and Technology[1][2][4]. Preclinical studies have shown that animals vaccinated with GLS-5140 remained healthy after challenge with a lethal dose of SFTSV[10].
- Other names
- GLS-5140GLS5140GLS 5140SFTS preventive DNA vaccine - GeneOne Life ScienceSFTSV DNA vaccine
02
Targets
SFTSV antigen (Severe fever with thrombocytopenia syndrome virus antigen)
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