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GLS-5310
- Development stage
- Phase 2
- Lead developer
- GeneOne Life Science
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intradermal
01
Overview
GLS-5310 is a bi-cistronic DNA vaccine developed for the prevention of COVID-19. It encodes both the SARS-CoV-2 spike (S) protein and the open reading frame 3a (ORF3a) antigen, with ORF3a included as an immunodominant T-cell antigen. The vaccine is administered intradermally followed by application of suction to enhance delivery using the GeneDerm device. Clinical studies have shown that GLS-5310 induces robust antibody and T-cell responses, with high levels of binding antibodies and persistent T-cell immunity observed up to 48 weeks post-vaccination. The mechanism of action involves inhibition of SARS-CoV-2 infection by eliciting immune responses against viral spike glycoprotein and ORF3a antigens[1][3][7].
02
Targets
SARS-CoV-2 spikeORF3a (SARS-CoV-2 ORF3a protein)
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