Glubran 2 (Gem)

Glubran 2 is a synthetic surgical glue and hemostatic agent composed of two monomers: n-butyl-2-cyanoacrylate (NBCA) and methacryloxysulfolane (MS). When it comes into contact with living tissue or moist environments containing ions, the monomers undergo a rapid exothermic polymerization reaction, creating a thin, elastic film with high tensile strength that adheres firmly to tissues. The inclusion of methacryloxysulfolane is a key modification that allows polymerization to occur at a lower temperature (approximately 45°C) compared to pure NBCA glues, reducing tissue thermal damage while providing greater flexibility to the resulting polymer. This combination is used for a variety of indications including hemostasis, tissue sealing, and wound closure across surgical, endoscopic, and endovascular procedures. It also possesses bacteriostatic properties that help prevent surgical site infections.

Brand names

Glubran 2Glubran2Glubran-2

Other names

n-butyl-2-cyanoacrylate + methacryloxysulfolaneNBCA-MS