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Glucion is a premixed, hypotonic intravenous maintenance solution containing glucose (5%), sodium chloride (providing 54 mmol/L of sodium), and potassium chloride (providing 26 mmol/L of potassium). It is designed for perioperative fluid maintenance to provide water, electrolytes, and calories while minimizing the risk of fluid retention and electrolyte imbalances. The solution is particularly studied in the context of thoracic surgery (e.g., the TOPMAST-1 trial) to compare its efficacy and safety against isotonic maintenance solutions, with a focus on preventing postoperative fluid overload and maintaining electrolyte homeostasis in fasting patients.
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