Drug intelligence / Profile preview

Glucion

Development stage
Phase 4
Lead developer
Takeda
Modality
Small Molecules
Administration
Intravenous
01

Overview

Glucion is a premixed, hypotonic intravenous maintenance solution containing glucose (5%), sodium chloride (providing 54 mmol/L of sodium), and potassium chloride (providing 26 mmol/L of potassium). It is designed for perioperative fluid maintenance to provide water, electrolytes, and calories while minimizing the risk of fluid retention and electrolyte imbalances. The solution is particularly studied in the context of thoracic surgery (e.g., the TOPMAST-1 trial) to compare its efficacy and safety against isotonic maintenance solutions, with a focus on preventing postoperative fluid overload and maintaining electrolyte homeostasis in fasting patients.

Brand names
GlucionGlucion 5%
Other names
sodium chloride + potassium chloride + glucose

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