Drug intelligence / Profile preview

Glucolevel

Development stage
Unknown
Lead developer
Al-Qasemi Research Center
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Glucolevel (also marketed as Glucose Level) is a traditional Arab herbal medicine-based botanical mixture containing dry leaf extracts of four plants: walnut (*Juglans regia*), olive (*Olea europaea*), nettle (*Urtica dioica*), and saltbush (*Atriplex halimus*). Developed through collaboration between the Galilee Society, the Antaki Center for Herbal Medicine, Al-Qasemi Research Center, and the Arab American University, and commercialized by Sprunk-Jansen, this combination is designed to help regulate blood glucose levels in patients with type 2 diabetes. The mixture acts via multiple synergistic mechanisms: the olive and walnut leaf extracts act as alpha-glucosidase inhibitors to reduce intestinal carbohydrate absorption, the nettle extract decreases hepatic glucose production, and the saltbush extract potentiates insulin action to facilitate glucose uptake into muscle and fat cells. Clinical and preclinical studies have demonstrated its safety, tolerability, and efficacy in lowering fasting blood glucose and HbA1c levels.

Brand names
GlucolevelGlucose Level
Other names
Juglans regia + Olea europaea + Urtica dioica + Atriplex halimusJuglans regia L. + Olea europea L. + Urtica dioica L. + Atriplex halimus L.glucolevel
02

Targets

Sucrase-IsomaltaseINSR (Insulin receptor)

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