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glucosamine + chondroitin sulfate + prednisolone + chloroquine

Development stage
Preclinical
Lead developer
Pierre Fabre
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination product containing four active ingredients: - **Glucosamine** and **chondroitin sulfate** are naturally occurring compounds commonly used as dietary supplements for the symptomatic management of osteoarthritis and joint pain. Glucosamine is thought to stimulate the formation and repair of articular cartilage, while chondroitin sulfate may inhibit enzymes that degrade cartilage. Both have mild anti-inflammatory effects but their efficacy in osteoarthritis remains controversial, with studies showing mixed results[1][2][3][5]. - **Prednisolone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts primarily by binding to the glucocorticoid receptor, modulating gene expression to suppress inflammation. - **Chloroquine** is an antimalarial agent also used as a disease-modifying antirheumatic drug (DMARD) in autoimmune diseases such as rheumatoid arthritis. It works by interfering with lysosomal activity and antigen presentation in immune cells. This specific four-drug combination does not appear to be marketed under any unique brand name or widely recognized formulation; it would represent an off-label or compounded therapy potentially aimed at severe inflammatory joint conditions where both symptom relief (glucosamine/chondroitin), immunosuppression (prednisolone), and DMARD action (chloroquine) are desired.

02

Targets

GR (Glucocorticoid receptor)NeuraminidaseARSB (N-acetylgalactosamine 4-sulfatase)

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