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glucose + insulin
- Development stage
- Phase 1
- Lead developer
- Aarhus University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This research intervention, developed by the University of Aarhus, involves the intravenous infusion of glucose and insulin during hemodialysis sessions for non-diabetic patients with end-stage renal disease (ESRD). The protocol aims to counteract the catabolic effects of hemodialysis by maintaining hyperinsulinemia, which in turn suppresses the hemodialysis-induced decrease in serum bioactive insulin-like growth factor-I (IGF-I) and reduces inflammatory markers. By preserving IGF-I bioactivity and modulating insulin-like growth factor binding protein-1 (IGFBP-1), the treatment seeks to improve the anabolic state of patients undergoing maintenance hemodialysis.
- Other names
- glucose-insulin infusion
02
Targets
INSR (Insulin receptor)IGF-1R (Insulin-like growth factor 1 receptor)IGFBP1 (Insulin-like growth factor-binding protein 1)
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