glucose-dependent insulinotropic polypeptide

Glucose-dependent insulinotropic polypeptide (GIP) is an endogenous 42-amino acid incretin hormone primarily synthesized by K-cells in the duodenum and jejunum. It plays a critical role in glucose homeostasis by binding to the GIP receptor (GIPR) on pancreatic beta cells, which enhances insulin secretion in response to elevated blood glucose levels. In addition to its insulinotropic effects, GIP influences lipid metabolism, bone density, and potentially cardiovascular function. Rigshospitalet in Denmark has utilized GIP infusions in clinical research to evaluate its effects on whole-body glucose uptake and organ perfusion in both healthy subjects and patients with type 2 diabetes mellitus, employing dynamic PET-CT imaging to quantify these physiological responses.

Other names

GIPgastric inhibitory polypeptide