Drug intelligence / Profile preview

glucuronolactone

Development stage
Unknown
Lead developer
Huazhong Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Glucuronolactone is a naturally occurring metabolite formed from the metabolism of glucose in the liver. It serves as an important structural component of nearly all connective tissues and is a precursor to glucuronic acid. In clinical medicine, it is primarily utilized as a hepatoprotective and detoxifying agent. It works by conjugating with various toxins, drugs, and metabolic waste products in the liver to form water-soluble glucuronides, which are then excreted in the urine. It is frequently used in the treatment of acute and chronic hepatitis, cirrhosis, and food or drug poisoning. Additionally, it is a well-known ingredient in energy drinks, where it is claimed to improve cognitive performance and detoxification, although its therapeutic use in liver disease remains its primary pharmaceutical application.

Brand names
AdroguronGlucurone
Other names
D-glucurono-3,6-lactoneD-glucuronic acid lactoneglucuronic acid lactone葡醛内酯
02

Targets

UGT (UDP-glucuronosyltransferase family)

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