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Glumin XR is an extended-release formulation of metformin hydrochloride, a biguanide antihyperglycemic agent developed and marketed by Dexa Medica Group. It is indicated for the management of type 2 diabetes mellitus, particularly in patients who are overweight and whose blood glucose levels are not adequately controlled by diet and exercise alone. Metformin works through several mechanisms: it decreases hepatic glucose production (gluconeogenesis), reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. The extended-release delivery system is designed to provide a gradual release of the active ingredient, which can improve gastrointestinal tolerability and patient adherence compared to immediate-release formulations. Dexa Medica Group markets this product in various Southeast Asian markets, including Indonesia and the Philippines.
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