glutaraldehyde-polymerized grass and rye allergen extract

Glutaraldehyde-polymerized grass and rye allergen extract is a **polymerized allergen immunotherapy vaccine** formulated by chemically modifying natural grass and rye pollen extracts using **glutaraldehyde cross-linking**. This process reduces the allergenic potential by masking IgE epitopes and significantly decreases proteolytic activity, thereby increasing the safety and stability of allergen extracts for clinical use[1][3][5][7]. The polymerization allows higher dosing and combining multiple allergen extracts for the treatment of patients allergic to both grass and rye pollens. These modified extracts are primarily indicated for **allergen immunotherapy** in patients with established allergies to grass and rye pollens. The vaccine is administered to help the patient develop immune tolerance, driven by stimulation of IgG responses and regulatory mechanisms (IL-10 secretion), while maintaining stability against enzymatic degradation present in multi-allergen formulations[1][3][5][7]. Glutaraldehyde-polymerized extracts can be combined with adjuvants such as aluminum hydroxide gel for subcutaneous immunotherapy[1][7].

Other names

glutaraldehyde-modified grass and rye allergen extractpolymerized grass pollen and rye allergen extractgrass pollen allergoid + rye allergoid