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glutathionylspermidine disulfide
- Development stage
- Unknown
- Modality
- Peptides, Small Molecules
01
Overview
Glutathionylspermidine disulfide is an experimental small molecule belonging to the class of oligopeptides. It is a dimeric disulfide form of glutathionylspermidine, a conjugate of glutathione and spermidine. This compound plays a crucial role in cellular redox balance and antioxidant defense, particularly in trypanosomes[7]. In humans, it interacts with mitochondrial glutathione reductase (GSR), which maintains high levels of reduced glutathione in the cytosol[1]. Glutathionylspermidine disulfide has been studied as a substrate for trypanothione reductase and is primarily used as a research tool rather than for therapeutic purposes[5].
- Other names
- N1-glutathionyl-spermidine disulfideN-1-glutathionyl-spermidine disulfideN 1-glutathionyl-spermidine disulfideN?-glutathionyl-spermidine disulfide[GLU(CYS-GLY-NH-(CH2)3-NH-(CH2)4-NH2)]2Glycinamide, L-γ-glutamyl-L-cysteinyl-N-[3-[(4-aminobutyl)amino]propyl]-, bimol. (2→2')-disulfideTS4TS-4TS 4
02
Targets
GSR (Glutathione reductase)
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