Glutor

Glutor is a potent, small-molecule inhibitor of the glucose transporters GLUT1, GLUT2, and GLUT3. By blocking these transporters, Glutor effectively inhibits glucose uptake and suppresses glycolytic metabolism, leading to a metabolic crisis and apoptosis in glucose-dependent cancer cells. It has demonstrated selective toxicity against cells harboring oncogenic mutations, such as JAK2V617F in myeloproliferative neoplasms (MPN), which induce a hypermetabolic state. Glutor is frequently utilized as a chemical probe in metabolic research to investigate the therapeutic potential of targeting glucose transport vulnerabilities in various malignancies and was originally identified by researchers at the Max Planck Institute of Molecular Physiology and the Lead Discovery Center.