Drug intelligence / Profile preview

Glutoxim

Development stage
Unknown
Lead developer
VAM
Modality
Peptides, Small Molecules
Administration
Intramuscular, Intravenous, Subcutaneous
01

Overview

Glutoxim is a synthetic disulfide peptide and an analog of oxidized glutathione (GSSG), developed and manufactured by Pharma VAM. It belongs to a class of innate defense regulators (IDRs) that modulate the body's internal defense systems through redox regulation. Specifically, the drug initiates redox processes involving the formation of disulfide bonds in extracellular and surface-cellular peptide molecules, leading to immunomodulatory, cytoprotective, and toxic-modifying effects. Glutoxim is approved in the Russian Federation for the complex therapy of various conditions, including tuberculosis (where it acts as an indirect antibacterial agent), oncological diseases (as a cytoprotector and immunomodulator), psoriasis, and sexually transmitted infections. Its mechanism involves stimulating bone marrow hematopoiesis and activating the phagocytic system, thereby restoring levels of neutrophils, monocytes, and lymphocytes in peripheral blood.

Brand names
GlutoximГлутоксим
Other names
Glutamyl-Cysteinyl-Glycine disodiumbis(L-gamma-glutamyl)-L-cystinyl-bis-glycine disodium saltOxidized glutathione disodium
02

Targets

SIGMAR1 (Sigma non-opioid intracellular receptor 1)Grx (Glutaredoxin)ABCB1 (P-glycoprotein)

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