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Drug intelligence / Profile preview
Gly-low
- Development stage
- Phase 1
- Lead developer
- Buck Institute for Research on Aging
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gly-low is a multi-ingredient dietary supplement cocktail developed by the University of California, San Francisco (UCSF) in collaboration with the Buck Institute for Research on Aging. It is composed of five FDA-recognized Generally Regarded As Safe (GRAS) compounds: alpha-lipoic acid, nicotinamide (vitamin B3), thiamine (vitamin B1), pyridoxamine (vitamin B6), and piperine. The formulation is designed to lower levels of methylglyoxal (MGO), a reactive byproduct of glycolysis, thereby reducing the formation of advanced glycation end-products (AGEs). By targeting the glycation pathway, Gly-low aims to mitigate age-related metabolic dysfunction, reduce food intake by modulating hypothalamic ghrelin signaling, and improve insulin sensitivity. It is currently being evaluated in Phase 1/2 clinical trials for the treatment of obesity and age-related conditions such as frailty and cognitive decline.
- Brand names
- GLYLO
- Other names
- Glycation lowering treatmentMGO lowering cocktail
02
Targets
GHSR (Growth hormone secretagogue receptor)
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