glyburide + fluconazole

This is a combination of two approved small molecule drugs, glyburide and fluconazole. Glyburide is a second-generation sulfonylurea used to improve glycemic control in adults with type 2 diabetes mellitus by stimulating insulin secretion from pancreatic beta cells through closure of ATP-sensitive potassium channels. Fluconazole is a triazole antifungal agent that inhibits fungal cytochrome P450 enzyme 14α-demethylase, impairing ergosterol synthesis and thus inhibiting fungal cell membrane formation. There is no fixed-dose combination product marketed under this name; however, co-administration may occur clinically. Notably, fluconazole can increase serum concentrations of glyburide by inhibiting its metabolism, raising the risk for hypoglycemia[1][3][6].