Drug intelligence / Profile preview

glycine nano-selenium

Development stage
Preclinical
Modality
Small Molecules, Nanoparticles → Drug Delivery Systems
Administration
Oral, Intraperitoneal
01

Overview

Glycine nano-selenium (NS-Gly) is a nanoparticle formulation of the trace element selenium, functionalized or stabilized with the amino acid glycine to improve bioavailability and reduce toxicity compared to inorganic selenium salts. It acts primarily as a potent antioxidant by upregulating the activity of key enzymes, including glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), thereby mitigating oxidative stress and lipid peroxidation. NS-Gly has been investigated for its potential as an immunomodulatory adjuvant to enhance vaccine responses (e.g., against H9N2 avian influenza) and as a neuroprotective agent in models of Parkinson's disease, where it helps preserve dopaminergic neurons. Additionally, it is studied as a nutritional supplement in poultry to support intestinal health and overall antioxidant capacity.

Other names
glycine-functionalized selenium nanoparticlesglycine-coated selenium nanoparticles
02

Targets

NeuraminidaseGPX4 (Glutathione peroxidase 4)Misfolded SOD1

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