Drug intelligence / Profile preview

glycopyrronium tosylate hydrate

Development stage
Approved
Lead developer
Journey Medical
Modality
Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Topical
01

Overview

Glycopyrronium tosylate hydrate is a topical anticholinergic agent used primarily for the treatment of primary axillary hyperhidrosis (excessive underarm sweating) in adults and pediatric patients aged 9 years and older. It is supplied as a pre-moistened cloth containing a 2.4% solution for once-daily application to the axillae. The drug acts as a competitive inhibitor of acetylcholine receptors on peripheral tissues such as sweat glands, thereby reducing sweat production by blocking cholinergic stimulation[2][5][6][8]. Glycopyrronium is classified pharmacologically as a muscarinic acetylcholine receptor antagonist and belongs to the class of neuropsychiatric agents with dermatological applications[8]. The product was developed for localized topical use to minimize systemic side effects associated with oral anticholinergics.

Brand names
QbrexzaRapifort
Other names
glycopyrronium tosylate monohydrateglycopyrronium tosilate hydrate
02

Targets

M1 (Muscarinic acetylcholine receptor M1)CHRM3 (M3)CHRM5 (M5)CHRM2 (M2)CHRM4 (M4)

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