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glycovir
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Glycovir is a small molecule investigational prodrug developed as an anti-HIV agent. It acts as an alpha-glucosidase 1 inhibitor and targets viral glycoprotein processing in the host cell endoplasmic reticulum. Glycovir itself is an ester prodrug of SC 48334; after administration, it is metabolized to the active compound which inhibits α-glycosidase 1. This mechanism disrupts the proper folding and maturation of viral envelope glycoproteins necessary for HIV infectivity. Glycovir was studied primarily for HIV infection treatment and reached phase II clinical trials, including combination studies with zidovudine (AZT). The drug was originally under development by Searle[1][2][4][5][7][8].
- Other names
- glycovirSC 49483SC49483SC-49483
02
Targets
Sucrase-Isomaltase
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