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Drug intelligence / Profile preview
Glycyl-L-a-Aminopimelyl-E-(D-2-Aminoethyl)Phosphonate
- Development stage
- Preclinical
- Modality
- Small Molecules, Peptides
01
Overview
Glycyl-L-a-Aminopimelyl-E-(D-2-Aminoethyl)Phosphonate is an experimental small molecule and peptide-based compound with the chemical formula C11H21N3O7P. It acts as a highly specific, slow, and irreversible inhibitor of D-alanyl-D-alanine carboxypeptidase/transpeptidases (DD-peptidases), which are beta-lactam-sensitive enzymes responsible for the final peptidoglycan cross-linking step in bacterial cell wall biosynthesis. By inhibiting this enzyme, it serves as a transition state analogue for the tetrahedral intermediate in the deacylation step of the carboxypeptidase reaction. This mechanism suggests potential utility in modulating glutamate levels and improving cognitive function, though its primary research focus has been on bacterial enzyme inhibition[4][6][8].
- Other names
- Glycyl-L-a-Aminopimelyl-E-(D-2-Aminoethyl)PhosphonateRE1RE-1RE 1
02
Targets
PBP (Penicillin-binding protein family)
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