Drug intelligence / Profile preview

glycyrrhiza flavescens subsp. antalyensis flower extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Glycyrrhiza flavescens subsp. antalyensis flower extract is a botanical extract derived from an endemic subspecies of licorice found only in the Antalya province of Turkey. In preclinical research, the aqueous extract has demonstrated antiproliferative and pro-apoptotic activity against melanoma cell lines. Its mechanism of action involves the induction of caspase-3 activity and the stimulation of pro-inflammatory cytokines, specifically tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ). As a complex natural product mixture, it is currently investigated in academic settings for its potential anticancer properties, particularly for the treatment of melanoma.

Other names
Glycyrrhiza flavescens subsp. antalyensis flower extract
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))IFNG (Interferon gamma)CASP3 (Caspase-3)

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