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glycyrrhiza protein
- Development stage
- Preclinical
- Modality
- Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
Glycyrrhiza protein is a proteinaceous extract derived from the *Glycyrrhiza* (licorice) plant. In preclinical research, it has been utilized both as a standalone agent and as a structural component in self-assembled nanoparticles (such as glycyrrhiza protein-paeoniflorin nanoparticles) for the treatment of rheumatoid arthritis. Its therapeutic effects are attributed to the modulation of glycerophospholipid metabolism and the downregulation of the PI3K/AKT/mTOR-NLRP3 signaling pathway. This leads to a reduction in synovial inflammation and the inhibition of pyroptosis-related factors like Caspase-1 and Gasdermin D.
- Other names
- GP
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)mTOR (Mammalian target of rapamycin kinase)CASP1 (Caspase-1)GSDMD (Gasdermin D)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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