Drug intelligence / Profile preview

glycyrrhiza uralensis extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Glycyrrhiza uralensis extract (also known as Chinese licorice extract) is a botanical extract derived from the roots and rhizomes of *Glycyrrhiza uralensis*. It is widely used in traditional Chinese medicine and has been investigated in modern research for its anti-inflammatory, antioxidant, antiviral, and hepatoprotective properties. The extract contains several bioactive constituents, including triterpenoid saponins (such as glycyrrhizin and glycyrrhetinic acid) and flavonoids (such as liquiritin, liquiritigenin, and isoliquiritigenin). It has been studied in clinical and preclinical settings for various indications, including dental caries, periodontal disease, halitosis, chronic obstructive pulmonary disease (COPD), rotavirus-induced gastroenteritis, and COVID-19. Its mechanisms of action involve the activation of the Nrf2 pathway, inhibition of NF-κB transactivation, and inhibition of aromatase activity.

Other names
Chinese licorice extractChinese liquorice extractGUEglycyrrhiza uralensis root extractULE
02

Targets

CYP19A1 (Aromatase)

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