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glycyrrhizic acid A
- Development stage
- Unknown
- Lead developer
- Shaanxi Fujie Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Glycyrrhizic acid A is a plant extract-derived small molecule active pharmaceutical ingredient (API) manufactured by Shaanxi Fujie Pharmaceutical. It is a triterpene glycoside extracted from the roots of the licorice plant (*Glycyrrhiza glabra*). The compound is widely recognized for its anti-inflammatory, antiviral, and hepatoprotective properties. Mechanistically, it is known to inhibit the enzyme 11-beta-hydroxysteroid dehydrogenase, which prevents the breakdown of cortisol, and it also acts as an inhibitor of high mobility group protein B1 (HMGB1), a key mediator in inflammatory pathways. Shaanxi Fujie Pharmaceutical produces this API in GMP-certified facilities for use in various pharmaceutical formulations, particularly those targeting chronic viral hepatitis and liver inflammatory conditions.
- Other names
- 甘草酸Aglycyrrhizinglycyrrhizic acidglycyrrhizinic acid
02
Targets
HSD11B1 (11-beta-hydroxysteroid dehydrogenase type 1)HSD11B2 (11β-HSD2)DNAESR1 (ERα)ESR2 (ERβ)HMGB1 (High mobility group protein B1)
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