Drug intelligence / Profile preview

glycyrrhizic acid A

Development stage
Unknown
Lead developer
Shaanxi Fujie Pharmaceutical
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Glycyrrhizic acid A is a plant extract-derived small molecule active pharmaceutical ingredient (API) manufactured by Shaanxi Fujie Pharmaceutical. It is a triterpene glycoside extracted from the roots of the licorice plant (*Glycyrrhiza glabra*). The compound is widely recognized for its anti-inflammatory, antiviral, and hepatoprotective properties. Mechanistically, it is known to inhibit the enzyme 11-beta-hydroxysteroid dehydrogenase, which prevents the breakdown of cortisol, and it also acts as an inhibitor of high mobility group protein B1 (HMGB1), a key mediator in inflammatory pathways. Shaanxi Fujie Pharmaceutical produces this API in GMP-certified facilities for use in various pharmaceutical formulations, particularly those targeting chronic viral hepatitis and liver inflammatory conditions.

Other names
甘草酸Aglycyrrhizinglycyrrhizic acidglycyrrhizinic acid
02

Targets

ESR2 (ERβ)ESR1 (ERα)HSD11B2 (11β-HSD2)DNAHSD11B1 (11-beta-hydroxysteroid dehydrogenase type 1)

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